MALDI Imaging Mass Spectrometry
Identifieur interne : 001E22 ( Main/Exploration ); précédent : 001E21; suivant : 001E23MALDI Imaging Mass Spectrometry
Auteurs : Julien Franck [France] ; Karim Arafah [France] ; Mohamed Elayed [France] ; David Bonnel [France] ; Daniele Vergara [France] ; Amélie Jacquet [France] ; Denis Vinatier ; Maxence Wisztorski [France] ; Robert Day [Canada] ; Isabelle Fournier [France] ; Michel Salzet [France]Source :
- Molecular & Cellular Proteomics : MCP [ 1535-9476 ] ; 2009.
Abstract
A decade after its inception, MALDI imaging mass spectrometry has become a unique technique in the proteomics arsenal for biomarker hunting in a variety of diseases. At this stage of development, it is important to ask whether we can consider this technique to be sufficiently developed for routine use in a clinical setting or an indispensable technology used in translational research. In this report, we consider the contributions of MALDI imaging mass spectrometry and profiling technologies to clinical studies. In addition, we outline new directions that are required to align these technologies with the objectives of clinical proteomics, including: 1) diagnosis based on profile signatures that complement histopathology, 2) early detection of disease, 3) selection of therapeutic combinations based on the individual patient's entire disease-specific protein network, 4) real time assessment of therapeutic efficacy and toxicity, 5) rational redirection of therapy based on changes in the diseased protein network that are associated with drug resistance, and 6) combinatorial therapy in which the signaling pathway itself is viewed as the target rather than any single “node” in the pathway.
Url:
DOI: 10.1074/mcp.R800016-MCP200
PubMed: 19451175
PubMed Central: 2742436
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MALDI Imaging Mass Spectrometry</title><author><name sortKey="Franck, Julien" sort="Franck, Julien" uniqKey="Franck J" first="Julien" last="Franck">Julien Franck</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Arafah, Karim" sort="Arafah, Karim" uniqKey="Arafah K" first="Karim" last="Arafah">Karim Arafah</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Elayed, Mohamed" sort="Elayed, Mohamed" uniqKey="Elayed M" first="Mohamed" last="Elayed">Mohamed Elayed</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Bonnel, David" sort="Bonnel, David" uniqKey="Bonnel D" first="David" last="Bonnel">David Bonnel</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Vergara, Daniele" sort="Vergara, Daniele" uniqKey="Vergara D" first="Daniele" last="Vergara">Daniele Vergara</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Jacquet, Amelie" sort="Jacquet, Amelie" uniqKey="Jacquet A" first="Amélie" last="Jacquet">Amélie Jacquet</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Vinatier, Denis" sort="Vinatier, Denis" uniqKey="Vinatier D" first="Denis" last="Vinatier">Denis Vinatier</name><affiliation><nlm:aff id="aff2">¶Service de gynécologie, Hôpital Jeanne de Flandre, 59037 Lille, France, and</nlm:aff><wicri:noCountry code="subfield">and</wicri:noCountry></affiliation></author><author><name sortKey="Wisztorski, Maxence" sort="Wisztorski, Maxence" uniqKey="Wisztorski M" first="Maxence" last="Wisztorski">Maxence Wisztorski</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Day, Robert" sort="Day, Robert" uniqKey="Day R" first="Robert" last="Day">Robert Day</name><affiliation wicri:level="1"><nlm:aff id="aff3">‖Département de Pharmacologie, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>‖Département de Pharmacologie, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4</wicri:regionArea><wicri:noRegion>Québec J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Fournier, Isabelle" sort="Fournier, Isabelle" uniqKey="Fournier I" first="Isabelle" last="Fournier">Isabelle Fournier</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19451175</idno><idno type="pmc">2742436</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742436</idno><idno type="RBID">PMC:2742436</idno><idno type="doi">10.1074/mcp.R800016-MCP200</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000B88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B88</idno><idno type="wicri:Area/Pmc/Curation">000B88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B88</idno><idno type="wicri:Area/Pmc/Checkpoint">000B10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B10</idno><idno type="wicri:Area/Ncbi/Merge">000A86</idno><idno type="wicri:Area/Ncbi/Curation">000A86</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A86</idno><idno type="wicri:doubleKey">1535-9476:2009:Franck J:maldi:imaging:mass</idno><idno type="wicri:Area/Main/Merge">001F71</idno><idno type="wicri:Area/Main/Curation">001E22</idno><idno type="wicri:Area/Main/Exploration">001E22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MALDI Imaging Mass Spectrometry</title><author><name sortKey="Franck, Julien" sort="Franck, Julien" uniqKey="Franck J" first="Julien" last="Franck">Julien Franck</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Arafah, Karim" sort="Arafah, Karim" uniqKey="Arafah K" first="Karim" last="Arafah">Karim Arafah</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Elayed, Mohamed" sort="Elayed, Mohamed" uniqKey="Elayed M" first="Mohamed" last="Elayed">Mohamed Elayed</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Bonnel, David" sort="Bonnel, David" uniqKey="Bonnel D" first="David" last="Bonnel">David Bonnel</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Vergara, Daniele" sort="Vergara, Daniele" uniqKey="Vergara D" first="Daniele" last="Vergara">Daniele Vergara</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Jacquet, Amelie" sort="Jacquet, Amelie" uniqKey="Jacquet A" first="Amélie" last="Jacquet">Amélie Jacquet</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Vinatier, Denis" sort="Vinatier, Denis" uniqKey="Vinatier D" first="Denis" last="Vinatier">Denis Vinatier</name><affiliation><nlm:aff id="aff2">¶Service de gynécologie, Hôpital Jeanne de Flandre, 59037 Lille, France, and</nlm:aff><wicri:noCountry code="subfield">and</wicri:noCountry></affiliation></author><author><name sortKey="Wisztorski, Maxence" sort="Wisztorski, Maxence" uniqKey="Wisztorski M" first="Maxence" last="Wisztorski">Maxence Wisztorski</name><affiliation wicri:level="3"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Villeneuve d'Ascq</settlement></placeName></affiliation></author><author><name sortKey="Day, Robert" sort="Day, Robert" uniqKey="Day R" first="Robert" last="Day">Robert Day</name><affiliation wicri:level="1"><nlm:aff id="aff3">‖Département de Pharmacologie, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>‖Département de Pharmacologie, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4</wicri:regionArea><wicri:noRegion>Québec J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Fournier, Isabelle" sort="Fournier, Isabelle" uniqKey="Fournier I" first="Isabelle" last="Fournier">Isabelle Fournier</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author><author><name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name><affiliation wicri:level="1"><nlm:aff id="aff1">From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>From the ‡MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, IFR 147, CNR-FRE 2933, University of Lille1, 59655 Villeneuve d'Ascq</wicri:regionArea><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion><wicri:noRegion>59655 Villeneuve d'Ascq</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular & Cellular Proteomics : MCP</title><idno type="ISSN">1535-9476</idno><idno type="eISSN">1535-9484</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A decade after its inception, MALDI imaging mass spectrometry has become a unique technique in the proteomics arsenal for biomarker hunting in a variety of diseases. At this stage of development, it is important to ask whether we can consider this technique to be sufficiently developed for routine use in a clinical setting or an indispensable technology used in translational research. In this report, we consider the contributions of MALDI imaging mass spectrometry and profiling technologies to clinical studies. In addition, we outline new directions that are required to align these technologies with the objectives of clinical proteomics, including: 1) diagnosis based on profile signatures that complement histopathology, 2) early detection of disease, 3) selection of therapeutic combinations based on the individual patient's entire disease-specific protein network, 4) real time assessment of therapeutic efficacy and toxicity, 5) rational redirection of therapy based on changes in the diseased protein network that are associated with drug resistance, and 6) combinatorial therapy in which the signaling pathway itself is viewed as the target rather than any single “node” in the pathway.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Villeneuve d'Ascq</li></settlement></list><tree><noCountry><name sortKey="Vinatier, Denis" sort="Vinatier, Denis" uniqKey="Vinatier D" first="Denis" last="Vinatier">Denis Vinatier</name></noCountry><country name="France"><region name="Hauts-de-France"><name sortKey="Franck, Julien" sort="Franck, Julien" uniqKey="Franck J" first="Julien" last="Franck">Julien Franck</name></region><name sortKey="Arafah, Karim" sort="Arafah, Karim" uniqKey="Arafah K" first="Karim" last="Arafah">Karim Arafah</name><name sortKey="Bonnel, David" sort="Bonnel, David" uniqKey="Bonnel D" first="David" last="Bonnel">David Bonnel</name><name sortKey="Elayed, Mohamed" sort="Elayed, Mohamed" uniqKey="Elayed M" first="Mohamed" last="Elayed">Mohamed Elayed</name><name sortKey="Fournier, Isabelle" sort="Fournier, Isabelle" uniqKey="Fournier I" first="Isabelle" last="Fournier">Isabelle Fournier</name><name sortKey="Jacquet, Amelie" sort="Jacquet, Amelie" uniqKey="Jacquet A" first="Amélie" last="Jacquet">Amélie Jacquet</name><name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name><name sortKey="Vergara, Daniele" sort="Vergara, Daniele" uniqKey="Vergara D" first="Daniele" last="Vergara">Daniele Vergara</name><name sortKey="Wisztorski, Maxence" sort="Wisztorski, Maxence" uniqKey="Wisztorski M" first="Maxence" last="Wisztorski">Maxence Wisztorski</name></country><country name="Canada"><noRegion><name sortKey="Day, Robert" sort="Day, Robert" uniqKey="Day R" first="Robert" last="Day">Robert Day</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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